MSCS Seminar Calendar
Wednesday September 11, 2024
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Bayesian Method of Borrowing Study-Level Historical Longitudinal Control Data for Mixed-effects Models with Repeated Measures
Dr. Hong Li (Takeda Pharmaceutical Company)
4:00 PM in 636 SEO
Bringing historical control information into a new trial appropriately holds the promise of more efficient trial design with more accurate estimates, increased power, and fewer patients allocated to inefficacious control group, provided the historical control data are sufficiently similar to the concurrent control. Interest has been growing over the past few decades in leveraging historical clinical trial on the control arm. However, most of the current historical borrowing methods focus on incorporating patient-level historical control information at only one time point. In this work, we propose a Bayesian hierarchical Mixed effect Models for Repeated Measures (BMMRM) to incorporate aggregated study-level longitudinal historical control estimates into the concurrent trial that collected repeated longitudinal data. The simulation study demonstrates that, as compared to one time point data analysis approach, leveraging longitudinal historical control data produces greater power enhancement and mitigates the power loss when the missing data under missing at random (MAR) mechanism is present. Our work also helps fill the gap of lack of methods borrowing historical longitudinal control data from the published summarized estimates when patient-level control data are not available.
Friday September 13, 2024
Monday September 16, 2024
Wednesday September 18, 2024
Friday September 20, 2024
Monday September 23, 2024
Friday September 27, 2024
Wednesday October 2, 2024
Wednesday October 23, 2024
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Organizational Effectiveness: A New Strategy to Leverage Multisite Randomized Trials for Valid Assessment
Guanglei Hong (University of Chicago)
4:00 PM in 636 SEO
In education, health, and human services, an intervention program is usually implemented by many local organizations. Determining which organizations are more effective is essential for theoretically characterizing effective practices and for intervening to enhance the capacity of ineffective organizations. In multisite randomized trials, site-specific intention-to-treat (ITT) effects are likely invalid indicators for organizational effectiveness and may lead to inequitable decisions. This is because sites differ in their local ecological conditions including client composition, alternative programs, and community context. Applying the potential outcomes framework, this study proposes a mathematical definition for the relative effectiveness of an organization. The estimand contrasts the performance of a focal organization with those that share the features of its local ecological conditions. The identification relies on relatively weak assumptions by leveraging observed control group outcomes that capture the confounding impacts of alternative programs and community context. We propose a two-step mixed-effects modeling (2SME) procedure. Simulations demonstrate significant improvements when compared with site-specific ITT analyses or analyses that only adjust for between-site differences in the observed baseline participant composition. We illustrate its use through an evaluation of the relative effectiveness of individual Job Corps centers by reanalyzing data from the National Job Corps Study, a multisite randomized trial that included 100 Job Corps centers nationwide serving disadvantaged youths. The new strategy promises to alleviate consequential misclassifications of some of the most effective Job Corps centers as least effective and vice versa.
Friday November 8, 2024
Friday November 15, 2024
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TBA
Noah Giansiracusa (Bentley University)
3:00 PM in 636 SEO
TBA
Please let Laura Schaposnik at schapos@uic.edu know if you'd like to join Noah for dinner, or if you'd like to meet him during the day. He's doing a lot of interesting interdisciplinary maths: https://www.noahgian.com/